Falsely elevated free thyroxine due to interference with anti-thyroxine autoantibodies
10.3760/cma.j.cn311282-20231026-00137
- VernacularTitle:抗甲状腺素自身抗体干扰导致游离甲状腺素假性升高
- Author:
Jing JIN
1
;
Zhongyan SHAN
;
Xiaochun TENG
Author Information
1. 中国医科大学附属第一医院内分泌与代谢病科，内分泌研究所，卫健委（共建）甲状腺疾病诊治重点实验室，沈阳 110001
- Keywords:
Thyroid hormone autoantibodies;
Immunoassay;
Detection interference
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(9):785-788
- CountryChina
- Language:Chinese
-
Abstract:
This article reports the clinica diagnosis and treatment of a 66-year-old male patient with elevated free thyroxine(FT 4) following coronavirus disease 2019(COVID-19) infection. The thyroid function tests showed a significant increase in FT 4, while thyroid stimulating hormone(TSH) was not suppressed. Re-testing on different platforms revealed inconsistent FT 4 elevations, indicating potential interference in FT 4 measurement. Radioimmunoprecipitation assays confirmed the presence of anti-thyroxine autoantibodies(T 4Ab) in the patient′s body, specifically the IgM subtype. This article reviews relevant literature, focusing on the identification and differential diagnosis of thyroid hormone autoantibodies interference.
