Enteroendocrine cell differentiation and function: An update
10.3760/cma.j.cn311282-20231113-00166
- VernacularTitle:胃肠内分泌细胞分化和功能研究进展
- Author:
Liying HUANG
1
;
Huan ZHANG
;
Yuming LI
;
Jiaoyue ZHANG
Author Information
1. 华中科技大学同济医学院附属协和医院内分泌科，湖北省糖尿病与代谢病临床研究中心，武汉 430022
- Keywords:
Enteroendocrine cell;
Gastrointestinal hormone;
Transcription factor;
Signaling pathways;
Organoid
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(6):538-544
- CountryChina
- Language:Chinese
-
Abstract:
Enteroendocrine cells are specialized hormone-secreting cells formed by the gradual differentiation of crypt stem cells in the intestine, which play a vital role in regulating metabolism. With advances in biological technologies, the roles of various transcription factors and signaling pathways in the differentiation stages of enteroendocrine cell have become clearer. In addition, the hormone secretion of enteroendocrine cells exhibits plasticity, influenced by different nutritional states and changes in gut microbiota, which affect the differentiation and functional regulation of enteroendocrine cells. Organoid models serve as novel in vitro culture models that facilitate further exploration into enteroendocrine cell functionality.
