Characteristics of gut microbiota of gestational diabetes mellitus and its impact on the glucose metabolism of their offspring

VernacularTitle:妊娠期糖尿病肠道菌群特征及其影响子代糖代谢的机制
Author: Sijia GUO ¹ ; Yimeng HU ; Huijuan YUAN
Author Information

1. 郑州大学人民医院内分泌科，河南省人民医院内分泌科，郑州　450003
Keywords: Gestational diabetes mellitus; Gut microbiota; Offspring; Glucose metabolism
From: Chinese Journal of Endocrinology and Metabolism 2024;40(6):529-533
CountryChina
Language:Chinese
Abstract: Gestational diabetes mellitus(GDM) is one of the most common complications during pregnancy, with increasing incidence in recent years, significantly affecting the health of both mothers and their offspring across generations. The exact pathogenesis of GDM remains unclear; However, growing evidence suggests that dysbiosis of gut microbiota is involved in the development of GDM, and further influences the establishment of microbiota in the next generation through vertical transmission. This article summarizes the differences in gut microbiota between GDM mothers and their offspring compared to healthy controls. In addition, we also discuss the impact of gut microbiota dysbiosis on metabolic health in GDM offspring and potential mechanisms involved, aiming to provide a reference for targeting gut microbiota in the prevention and treatment of GDM and its complications in offspring.