Median effective dose of sufentanil in inhibiting responses to tracheal intubation when combined with ciprofol in patients with Parkinson′s disease
10.3760/cma.j.cn131073.20240122.00614
- VernacularTitle:复合环泊酚时舒芬太尼抑制帕金森病患者气管插管反应的半数有效剂量
- Author:
Fengmei MEI
1
;
Wenbin ZHANG
;
Qiong ZENG
;
Yifeng RUAN
;
Jun LU
Author Information
1. 南京医科大学附属脑科医院麻醉科，南京 210029
- Keywords:
Sufentanil;
Ciprofol;
Intubation, endotracheal;
Dose-response relationship, drug;
Parkinson disease
- From:
Chinese Journal of Anesthesiology
2024;44(6):714-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the median effective dose (ED 50) of sufentanil in inhibiting responses to tracheal intubation when combined with ciprofol in patients with Parkinson′s disease. Methods:This was a prospective study. American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients with Parkinson′s disease, aged 18-64 yr, with body mass index of 18.5-30.0 kg/m 2, of Mallampati grade Ⅰ or Ⅱ, undergoing elective deep brain stimulator implantation with tracheal intubation in the Brain Hospital Affiliated to Nanjing Medical University from July 2022 to January 2024, were selected. Sufentanil, ciprofol 0.40 mg/kg and rocuronium 0.60 mg/kg were administrated intravenously and sequentially, and endotracheal intubation was performed after onset of muscle relaxation. A positive response was defined as an increase in heart rate or mean arterial pressure by more than 20% of the baseline value within 2 min after tracheal intubation. The initial dose of sufentanil was set at 0.36 μg/kg, the dose in the next patient was determined according to the response to tracheal intubation, and the ratio between the two successive doses was 1.2. The ED 50 and 95% confidence interval of sufentanil in inhibiting responses to tracheal intubation were calculated using the Dixon-Mood method. Results:The ED 50 (95% confidence interval) of sufentanil in inhibiting responses to tracheal intubation was 0.335 (0.298-0.378) μg/kg when combined with ciprofol. Conclusions:When combined with ciprofol 0.40 mg/kg, the ED 50 of sufentanil in inhibiting responses to tracheal intubation is 0.335 μg/kg in patients with Parkinson′s disease.
