Effect of strict intraoperative blood glucose control on postoperative hepatic allograft dysfunction in patients undergoing liver transplantation
10.3760/cma.j.cn131073.20231106.00504
- VernacularTitle:术中严格血糖控制对肝移植术患者术后肝功能障碍的影响
- Author:
Lei CUI
1
;
Yi DUAN
;
Zhifeng GAO
;
Jiaojiao GUO
;
Zheng ZHANG
;
Huan ZHANG
Author Information
1. 清华大学附属北京清华长庚医院麻醉科 清华大学临床医学院，北京 102218
- Keywords:
Liver transplantation;
Glycemic control;
Primary graft dysfunction
- From:
Chinese Journal of Anesthesiology
2024;44(5):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of strict intraoperative blood glucose control on postoperative hepatic allograft dysfunction in patients undergoing liver transplantation.Methods:A total of 164 patients of both sexes, aged 18-64 yr, with body mass index of 18-30 kg/m 2, of American Society of Anesthesiologists Physical Status classification Ⅲ or Ⅳ, undergoing orthotopic liver transplantation, were divided into strict intraoperative blood glucose control group (group S, 6.0-7.8 mmol/L) and routine blood glucose control group (group C, 4.1-10.0 mmol/L) using a random number table method. From the completion of anesthesia induction to the end of operation, arterial blood glucose was measured every 1 h, and blood glucose management was carried out in combination with the goal-oriented blood glucose control process. The occurrence of postoperative hepatic allograft dysfunction, infection within 30 days after surgery, offline extubation time, duration of intensive care unit stay and total length of hospital stay were recorded. Results:Compared with group C, the incidence of postoperative liver dysfunction and infection within 30 days after operation were significantly decreased ( P<0.05), and no significant change was found in the offline extubation time, duration of intensive care unit stay and total length of hospital stay in group S ( P>0.05). Conclusions:Strict blood glucose control during liver transplantation can decrease the development of postoperative liver dysfunction in patients.
