Research progress on the role of nicotinamide mononucleotide(NMN)in anti-aging and treatment of aging-associated diseases

VernacularTitle:烟酰胺单核苷酸在抗衰老和衰老相关疾病治疗中的作用研究进展
Author: Xinyan LI ¹ ; Qing YIN ; Bicheng LIU
Author Information

1. 东南大学附属中大医院肾脏科，南京　210009
Keywords: Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Aging
From: Chinese Journal of Geriatrics 2024;43(10):1338-1344
CountryChina
Language:Chinese
Abstract: Nicotinamide adenine dinucleotide(NAD + ), a coenzyme for redox reactions crucial to energy metabolism, is also a required co-substrate for non-redox NAD + -dependent enzymes.NAD + participates in a wide range of biological functions within cells, including energy metabolism, DNA repair, cellular senescence, and epigenetics.It is also closely correlated with aging and aging-associated disorders.Recent research has indicated that supplementation with nicotinamide mononucleotide(NMN), a precursor of NAD +, can increase NAD + levels and has excellent preventive and therapeutic potential in a variety of age-related diseases, such as cardiovascular diseases, neurodegenerative diseases, renal diseases, endocrine and metabolic diseases, reproductive system diseases and malignant tumors.This paper provided a comprehensive review of recent research advances on NAD + metabolism and the role of NMN in anti-aging and aging-associated diseases.