Research progress on mechanisms of resistance to fluconazole of vaginal Candida albicans

VernacularTitle:阴道白念珠菌对氟康唑耐药机制的研究进展
Author: Yujun YIN ¹ ; Weiping CAO ; Wei LI
Author Information

1. 江苏大学第四附属医院妇科，镇江　212001
Keywords: Vulvovaginal candidiasis; Candida albicans; Fluconazole; Mechanisms of drug resistance
From: Chinese Journal of Clinical Infectious Diseases 2024;17(2):156-160
CountryChina
Language:Chinese
Abstract: Vulvovaginal candidiasis（VVC）is an opportunistic infection of the vaginal mucosa mainly caused by Candida albicans， which is the second most common vaginal infection other than bacterial vaginosis. The azole antifungal agent fluconazole is the drug of the first choice for treatment of VVC. With the widespread and non-standard use in clinical practice，the resistance of Candida albicans to fluconazole is on the rise. This article reviews the mechanisms of vaginal Candida vaginalis resistance to fluconazole，including the target mutations or high expression of drug action-related genes，the overexpression of drug efflux pump，the regulation of stress response，and the formation of biofilms，in order to provide information for a new strategy of VVC treatment.