Meta-analysis on correlation between hepatitis C virus infection and risk of cholangiocarcinoma
10.3877/cma.j.issn.2095-3232.2015.02.005
- VernacularTitle:丙型肝炎病毒感染与胆管细胞癌发生风险关系的Meta分析
- Author:
Hao LI
1
;
Zhengjun ZHANG
;
Zunqiang ZHOU
;
Guangwen ZHOU
Author Information
1. 200080上海交通大学附属第一人民医院普通外科1
- Keywords:
Hepacivirus;
Bile duct neoplasms;
Intrahepatic cholangiocarcinoma;
Meta-analysis
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2015;(2):79-83
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the correlation between hepatitis C virus infection and the risk of cholangiocarcinoma (CCA) through Meta-analysis.MethodsLiteratures that were formally published prior to August, 2013 were searched on National Knowledge Infrastructure (CNKI), PubMed, EMBASE and MEDLINE databases using English, Chinese terms mainly including hepatitis C virus, HCV, cholangiocarcinoma, bile duct cancer, intrahepatic, extrahepatic. Moreover, associated literatures were also searched by manual searching. Data from the literatures were merged and the correlation between hepatitis C virus and risk of CCA, intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC) was analyzed respectively. Heterogeneity test was conducted usingQ test.RR value of each study and pooled data were calculated and forest graph was drawn to display the results and features of each study. Funnel plot and Egger test were used to identify the publication bias.ResultsA total of 16 case-control studies and 2 cohort studies (total 873 501 patients) were included in the ifnal analysis. Meta-analysis showed that hepatitis C virus infection was not associated with the occurrence of CCA (RR=2.36,P>0.05) and hepatitis C virus infection was the risk factor for the occurrence of ICC and ECC (RR=4.10, 1.48;P<0.05).Funnel plot and Egger test showed no evidence for publication bias.ConclusionHepatitis C virus infection is associated with the risks of ICC and ECC, especially ICC.
