Advances in osteoinductivity and tissue engineering applications of β-TCP
10.3760/cma.j.cn121113-20231006-00215
- VernacularTitle:β-磷酸三钙的骨诱导性和组织工程应用研究进展
- Author:
Jinzhou DU
1
;
Yun QIAN
;
Cunyi FAN
Author Information
1. 上海交通大学医学院附属第六人民医院（国家骨科医学中心）骨科，上海 200233
- Keywords:
Calcium phosphates;
Tissue engineering;
Bone defect
- From:
Chinese Journal of Orthopaedics
2024;44(13):906-914
- CountryChina
- Language:Chinese
-
Abstract:
The use of autogenous bone in treating bone defects has not met clinical demands, leading to increased attention on beta-tricalcium phosphate (β-TCP) as a bone graft substitute due to its effective repair capabilities and inherent osteoinductive properties. Upon implantation, biodegradable β-TCP can effectively modulate inflammation, promote vascular regeneration, and facilitate new bone formation through intramembranous ossification, thereby achieving bone defect healing. Continuous research has sought to understand the mechanisms underlying β-TCP's ability to induce mesenchymal stem cell differentiation into osteoblasts, initially attributed to the release of calcium and phosphorus ions and the adsorption of proteins. Current research emphasizes the impact of the material's surface structure on cellular interactions, particularly focusing on changes in cell-integrin and cytoskeleton dynamics, which regulate signal transduction pathways such as the mitogen-activated protein kinase/extracellular signal-regulated kinases (MAPK/ERK) pathway, the Wnt pathway, and the Yes-associated protein/transcriptional coactivator with PDZ-binding motif (Yap/Taz) pathway. Presently, the fundamental structure of β-TCP products has matured, with continuous innovations in macro and micro design. These bone graft substitutes are widely used in clinical settings, demonstrating long-term safety and efficacy.
