Study on the effect of imaging index in predicting the tumorous polyps of gallbladder
10.3760/cma.j.cn113884-20240829-00261
- VernacularTitle:影像学指标预测胆囊肿瘤性息肉效果的研究
- Author:
Chang LIU
1
;
Gang LI
Author Information
1. 北京大学第三医院外科基地，北京 100191
- Keywords:
Gallbladder diseases;
Forecasting;
Color doppler ultrasound;
Magnetic resonance cholangiopancreatography
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(11):851-855
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of imaging index in predicting the tumorous polyps of gallbladder.Methods:Clinical data of 223 patients undergoing cholecystectomy due to polypoid lesion of gallbladder (PLG) in Peking University Third Hospital from September 2021 to April 2023 were retrospectively analyzed, including 94 males and 129 females, aged (48.0±13.9) years. According to postoperative pathology, patients were divided into the tumorous polyp group ( n=51, including 50 adenomatous polyps and one adenocarcinoma) and a non-tumorous polyp group ( n=172, all were cholesterol polyps). The two groups were compared in terms of concomitant malignant tumors (breast cancer, thyroid cancer, etc.), long diameter of polyp by ultrasound, combined gallstones, and slightly short T 1 signal and short T 1 signal of magnetic resonance cholangiopancreatography (MRCP) of polyps. The variables with P<0.1 between the groups were further substituted into multivariate logistic regression to analyze the influencing factors of gallbladder tumorous polyps. The receiver operating characteristic (ROC) curve was used to analyze the predictive effect. Results:The proportion of patients with concomitant malignant tumors was higher in tumorous polyp group than that in non-tumorous polyp group ( χ2=5.29, P=0.021). Compared with the non-tumorous polyps, the tumorous polyps were larger in diameter, less combined with gallstones, and with more slightly short T 1 signals and short T 1 signals (all P<0.05). The variables with P<0.1, such as with other concomitant malignant tumors, slightly short T 1 and short T 1 signals on MRCP, male, and combined with gallstones, were further substituted into the multivariate logistic regression analysis, which showed that patients with larger polyps ( OR=3.665, 95% CI: 1.567-8.573), combined with gallbladder stones ( OR=3.027, 95% CI: 1.234-7.426) had an increased risk of tumorous polyps, with other concomitant malignant tumors ( OR=0.200, 95% CI: 0.052-0.765) had decreased risk of tumorous polyps (all P<0.05). The area under the ROC curve (AUC) of the long diameter of polyp to predict tumorous polyps was 0.722 (95% CI: 0.643-0.801). When the long diameter of polyp was 1.05 cm, the predictive sensitivity was 82.4% and the specificity was 43.6%. Conclusion:The long diameter of polyps, combined with gallbladder stones, and with other concomitant malignant tumors are influencing factors for tumorous polyps of gallbladder. The long diameter of polyps measured by ultrasound has a good predictivity of tumorous polyps.
