Research progress of animal models of severe acute pancreatitis

VernacularTitle:重症急性胰腺炎动物模型的研究进展
Author: Hongli YANG ¹ ; Feifei ZHOU ; Ben WANG ; Qianqian XU ; Weijia SUN ; Hongwei XU
Author Information

1. 山东第一医科大学附属省立医院消化内科，济南　250021
Keywords: Pancreatitis; Severe acute pancreatitis; Animal models; Research progress
From: Chinese Journal of Hepatobiliary Surgery 2024;30(10):797-800
CountryChina
Language:Chinese
Abstract: Severe acute pancreatitis (SAP) is a serious disease commonly encountered in the emergency department and can precipitate systemic inflammatory response syndrome and multiple organ dysfunction syndrome with high morbidity and mortality. However, its etiology and pathogenesis are complex and have not been fully elucidated. Clinical studies can provide some data on the etiology, pathophysiology, and outcome associated with the disease. However, research on SAP cannot be carried out in humans directly for ethical considerations. It is very important to establish an appropriate animal model of SAP to elucidate its pathogenesis and seek innovative therapeutic methods. In this paper, we reviewed the latest research progress at home and abroad in animal models of SAP over the past several years.