Research progress in animal models of liver regeneration based on the different injury modalities
10.3760/cma.j.cn113884-20240425-00116
- VernacularTitle:基于损伤模式建立肝再生小鼠模型的研究进展
- Author:
Qian QIU
1
;
Hui ZHANG
;
Hehe YIN
;
Honghai XU
Author Information
1. 安徽医科大学第一附属医院病理科，合肥 230022
- Keywords:
Hepatectomy;
Liver regeneration;
Liver injury;
Chemical drug;
Gene editing;
Clinical intervention therapy
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(7):552-556
- CountryChina
- Language:Chinese
-
Abstract:
The liver is a solid organ with excellent regenerative potential. Its regenerative ability is closely related to liver disease. In-depth study of the mechanism of liver regeneration is of great significance for understanding liver biology and developing regenerative medicine. The mouse has been the most widely used animal model of liver regeneration for its technical, economic and anatomical advantages. The current mouse models of liver regeneration include partial liver resection, chemical drug injury, and genetic engineering models. In this review, we compared their advantages, shortcomings and application prospects to provide reference for future research.
