Research progress in the mechanism of m 6A RNA methylation modification in radiotherapy for malignant tumors
10.3760/cma.j.cn113030-20230530-00137
- VernacularTitle:RNA的N 6-甲基腺嘌呤甲基化在肿瘤放疗中的作用研究进展
- Author:
Rui QUAN
1
;
Guanghui CHENG
;
Ning WU
Author Information
1. 吉林大学中日联谊医院放射治疗科，长春 130033
- Keywords:
Radiotherapy;
N 6 methyladenine;
Epigenetic transcriptomics
- From:
Chinese Journal of Radiation Oncology
2024;33(5):472-478
- CountryChina
- Language:Chinese
-
Abstract:
Many epigenetic transcriptome studies have found that N 6 methyladenine (m 6A) methylation, as the most abundant chemical modification on eukaryotic mRNA, plays an important role in the occurrence and development of malignant tumors. It might affect the effectiveness and prognosis of tumor radiotherapy by regulating radiation induced DNA damage, participating in radiation resistance of tumor stem cells, controlling tumor radiosensitivity, intervening in radiation related adverse reactions, and optimizing the synergistic effect of radiotherapy combined with other treatments. In this article, the research progress in the epigenetic mechanism of m 6A RNA methylation modification in tumor radiotherapy was reviewed, aiming to provide ideas for exploring potential new targets for tumor radiotherapy and searching for radiation sensitization and toxicity reduction biomarkers.
