Advances in research on the role and mechanism of ferroptosis in radiation-induced injury

VernacularTitle:铁死亡在放射损伤中的作用及机制研究进展
Author: Qingxin WANG ¹ ; Zhongqiu WANG ; Wei WANG ; Peiguo WANG
Author Information

1. 天津医科大学肿瘤医院放射治疗科　国家恶性肿瘤临床医学研究中心　天津市恶性肿瘤临床医学研究中心　天津市肿瘤防治重点实验室，天津　300060
Keywords: Radiotherapy; Radiation-induced injury; Ferroptosis
From: Chinese Journal of Radiological Medicine and Protection 2024;44(6):537-542
CountryChina
Language:Chinese
Abstract: Radiotherapy plays an important role in the comprehensive treatment of malignant tumors. Radiation-induced injury (RII) of normal tissue in tumor patients receiving radiotherapy, to varying degrees, is the most common adverse reaction of radiotherapy and an important factor influencing the course of radiotherapy. However, there is a lack of efficient prevention and treatment measures for RII. Ferroptosis, a novel type of cell death, has been reported several times to be closely associated with normal tissue damage induced by radiotherapy. This paper reviews the advances in research on ferroptosis, as well as its mechanism and association with RII.