Clinical characteristics and treatment of 17 cases with Vibrio vulnificus sepsis
10.3760/cma.j.cn311365-20240314-00064
- VernacularTitle:创伤弧菌脓毒症患者17例的临床特征及诊治
- Author:
Lizhi LI
1
;
Wei HUANG
;
Jing CHEN
;
Hao XU
Author Information
1. 厦门市重症医学质量控制中心，厦门大学附属第一医院重症医学科，厦门 361003
- Keywords:
Vibrio vulnificus;
Sepsis;
Prognosis;
Surgical treatment
- From:
Chinese Journal of Infectious Diseases
2024;42(7):403-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features of Vibrio vulnificus sepsis, so as to provide the basis for clinical diagnosis and treatment, and reducing the mortality rate and improving the prognosis. Methods:The clinical data of 17 patients with Vibrio vulnificus sepsis were retrospectively collected from the First Affiliated Hospital of Xiamen University from April 2018 to February 2024. Univariate analysis was used to compare the differences of laboratory examinations between the death group (five cases) and the survival group (12 cases). The study was clinical retrospective case-control study. Independent sample t test and Mann-Whitney U test were used as statistical methods when appropriate. Results:Among 17 patients with Vibrio vulnificus sepsis, there were 11 males and six females, aged (63±14) years. Eight cases had a history of handling seafood, three cases had a history of trauma after engaging in sea activities, one case had consumed seafood, and the remaining five cases had unknown causes.Univariate analysis showed that white blood cell count (3.6(2.9, 6.8)×10 9/L vs 12.1(7.4, 21.2)×10 9/L), the platelet count ((40.0±30.4)×10 9/L vs (117.8±76.7)×10 9/L) and fibrinogen level (2.3(2.1, 2.4) g/L vs 3.9(2.9, 6.4) g/L) in the death group were all lower than those in the survival group ( Z=-2.42, t=2.16 and Z=-2.11, respectively, all P<0.05). And the procalcitonin level (89.0 (31.9, 100.0) mg/L vs 23.2(5.4, 47.2) mg/L), thrombin time (17.7(16.2, 30.8) s vs 15.2(14.2, 15.7) s), aspartate aminotransferase level (215.0(75.5, 1 240.5) U/L vs 32.0(20.3, 47.8) U/L), total bilirubin (68.4 (42.0, 93.8) μmol/L vs 21.4 (14.1, 30.5) μmol/L), creatine kinase (7 899.0(364.5, 19 474.5) U/L vs 185.5(40.5, 333.5) U/L) and creatinine ((159.6±61.7) μmol/L vs (79.3±42.4) μmol/L) in the death group were all higher than those in the survival group ( Z=-2.42, -2.22, -2.16, -2.11 and -2.74, t=-3.13, respectively, all P<0.05). The differences were all statistically significant. Conclusions:Vibrio vulnificus infection is highly lethal. Creatine kinase, creatinine and procalcitonin levels in the death group are higher than those in the survival group, while the white blood cell count is lower than that in the surviving group.
