Progress in Basic Research on the Intervention of Chinese Materia Medica in Diabetes Kidney Disease through SIRT1 Signaling Pathway
10.19879/j.cnki.1005-5304.202310437
- VernacularTitle:中药通过SIRT1信号通路干预糖尿病肾病基础研究进展
- Author:
Yaping HE
1
;
Dengke JIA
;
Xiaowei SHI
Author Information
1. 甘肃中医药大学,甘肃 兰州 730000
- Keywords:
diabetic kidney disease;
TCM;
SIRT1 signaling pathway;
oxidative stress;
inflammatory response;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(8):182-187
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is the leading cause of end-stage renal disease.Chinese materia medica shows unique advantages in intervening DKD.Silent information regulator 1(SIRT1)protein plays a vital role in the occurrence and development of DKD.This article was about the SIRT1 signaling pathway and the main molecular regulatory mechanisms to sort out the role of Chinese materia medica in regulating SIRT1 in podocytes,oxidative stress and inflammatory response.It was found that Chinese materia medica monomers and compounds were capable of regulating the PGC-1 α signaling pathway,Nrf2/ARE signaling pathway,AMPK signaling pathway,NF-κB p65 signaling pathway,and PI3K/AKT/FoxO1 signaling pathway by targeting SIRT1,exerting pharmacological effects such as inhibiting cell apoptosis,improving mitophagy,inhibiting inflammatory response,etc.,thus intervening in DKD,which can provide reference for relevant research.
