Discussion on the Effects of Tumor-associated Macrophages Polarization on Lung Cancer Based on the TCM Yin-yang Theory
10.19879/j.cnki.1005-5304.202308012
- VernacularTitle:基于中医阴阳理论探讨肿瘤相关巨噬细胞极化在肺癌中的作用
- Author:
Yu WANG
1
;
Lu ZHANG
;
Simin HUANG
;
Dongdong YU
;
Leilei TANG
;
Tingting LU
Author Information
1. 安徽中医药大学中西医结合学院,安徽 合肥 230012
- Keywords:
tumor-associated macrophages;
phenotype;
balance of yin and yang;
lung cancer
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(7):14-19
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the cancer type with the highest incidence rate and mortality among malignant tumors in China.Tumor associated macrophages(TAMs)are closely related to the occurrence,development,invasion and metastasis,and treatment tolerance of lung cancer.This article explored the etiology and pathogenesis of lung cancer in TCM,as well as the key role of TAMs in lung cancer.It was found that the local imbalance of yin and yang in TAMs,as well as the overall imbalance of yin and yang in the tumor microenvironment and whole body,were important reasons for the formation and progression of lung cancer.In the progression and sequelae of lung cancer,M1 and M2 type TAMs each plays different roles and has different yin and yang properties.Both of them maintain a constantly developing and changing state of mutual use,opposing constraints,and balance of growth and decline.Based on the yin-yang theory in TCM,according to the progression of lung cancer and the imbalance of yin and yang,rational selection and medication can adjust the phenotype of TAMs,promote the overall balance of yin and yang,and provide reference for the clinical prevention and treatment of lung cancer.
