Advances in the study of tertiary lymphoid structures in tumors
10.12354/j.issn.1000-8179.2024.20240801
- VernacularTitle:三级淋巴结构在肿瘤中的研究进展
- Author:
Wang SHUO
1
;
Yue DONGSHENG
Author Information
1. 天津医科大学肿瘤医院肺部肿瘤科,国家恶性肿瘤临床医学研究中心,天津市肺癌中心实验室,天津市肿瘤防治重点实验室(天津市 300060)
- Keywords:
tertiary lymphoid structures(TLSs);
neoplasms;
prognosis
- From:
Chinese Journal of Clinical Oncology
2024;51(17):866-872
- CountryChina
- Language:Chinese
-
Abstract:
Tertiary lymphoid structures(TLSs),also known as tertiary lymphoid structures or ectopic lymphoid structures,are organized ag-gregates of immune cells that develop later in life in non-lymphoid tissues and that are structurally and functionally similar to secondary lymphoid structures.Additionally,TLSs are often associated with non-neoplastic diseases,such as autoimmune diseases and chronic inflam-matory disorders.The presence of TLSs in a variety of tumors has been revealed in recent studies to be strongly associated with patient pro-gnosis;however,its role in predicting prognosis varied in different types of tumors,which may be related to the location,maturity,and func-tion of TLSs in tumor tissue.Currently,a comprehensive identification of the state profile of TLSs is insufficient,which limits our assessment of its potential as a prognostic marker.In this study,we comprehensively analyzed the distribution characteristics of TLSs in different tumor types and explored its role in tumor therapy,as well as the potential and value of TLS as a prognostic predictive marker.
