Role of circular RNA in the development and diagnosis of non-small cell lung cancer

VernacularTitle:环状RNA在非小细胞肺癌发生发展和诊疗作用中的进展
Author: Wei DU ¹ ; Dawei HUANG ; Xiaowei WU ; Jie WANG ; Xue YI
Author Information

1. 福建医科大学公共卫生学院，福州　350122
Keywords: Non-small cell lung cancer; Circular RNA; Biological function
From: Clinical Medicine of China 2024;40(4):307-311
CountryChina
Language:Chinese
Abstract: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and still has the highest mortality rate. The occurrence and development of non-small cell lung cancer are related to multi gene regulation. Circular RNA is a non coding RNA formed by reverse splicing, which is widely expressed in many types of biological cells. Circular RNA lacks 5' and 3' terminals, and compared to linear RNA, circular RNA has better stability towards exonuclease and ribonuclease. With the development of high-throughput sequencing and bioinformatics technology, the correlation between more and more circular RNAs and tumors is gradually being recognized. This article provides a review on the role of circular RNA in the occurrence, development, diagnosis, and treatment of non-small cell lung cancer, aiming to provide new ideas for further research on its mechanism.