Application Progress of Ultrasound Microbubble Combined with Cavitation Effect in Sonodynamic Therapy of Malignant Tumors
10.3969/j.issn.1005-5185.2024.09.020
- VernacularTitle:超声微泡联合空化效应在声动力治疗恶性肿瘤中的应用进展
- Author:
Dan ZHANG
1
;
Xiaoshan ZHANG
;
Xiaoxiao LIU
;
Jie ZHAO
;
Yaxi WANG
Author Information
1. 内蒙古医科大学附属医院超声科,内蒙古呼和浩特 010050
- Keywords:
Neoplasms;
Ultrasonography;
Microbubble;
Cavitation;
Sonodynamic therapy;
Review
- From:
Chinese Journal of Medical Imaging
2024;32(9):972-976
- CountryChina
- Language:Chinese
-
Abstract:
Sonodynamic therapy is a novel treatment for killing malignant tumors with sonic sensitizers and low-intensity ultrasound,which via ultrasonic mechanical stress,the effects of ultrasonic cavitation and the combined production of ultrasound and acoustic sensitizers produce reactive oxygen species induces apoptosis co-destructing target cells.Compared with traditional approaches for the treatment of malignancy,sonodynamic therapy has advantages of greater accuracy,deeper tissue penetration,better patient dependency,and less side effects.Ultrasound microsphere contrast agents can significantly enhance the effects of cavitation as synthetic cavitation nuclei,and precise regulation of the effects of cavitation is a key factor in improving the efficiency of sonodynamic therapy.The combination of ultrasonic microspheres and adjustable cavitation have broad prospects in the field of sonodynamic therapy for malignant tumors.
