Antimicrobial effect of cefixime on 6 species of periodotopathogens.
10.5051/jkape.2005.35.2.401
- Author:
Hyun Seon JANG
1
;
Mun Gyu PARK
;
Joong Ki KOOK
;
Hwa Sook KIM
;
Byung Ock KIM
Author Information
1. Department of Periodontology, College of Dentistry, Chosun University, Korea. bobkim@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Minimal inhibitory concentraion(MIC);
cefixime
- MeSH:
Aggregatibacter actinomycetemcomitans;
Amoxicillin;
Anti-Bacterial Agents;
Cefixime*;
Ciprofloxacin;
Forsythia;
Fusobacterium nucleatum;
Metronidazole;
Porphyromonas gingivalis;
Prevotella;
Prevotella nigrescens;
Volunteers
- From:The Journal of the Korean Academy of Periodontology
2005;35(2):401-411
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The aim of this study was to determine the minimal inhibitory concentration(MIC) of cefi- xime, which is a 3rd generation of cefalosporin, against 6 species of putative periodon- topathogens; Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Prevotella inter- media, Prevotella nigrescens, Tannerella forsythia and Porphyromonas gingivalis. The efficacy of cefixime was examined by comparing it with that of several antibiotics(amoxicillin, Aug- mentin(R) ciprofloxacin, metronidazole, and tetracycline), which were used as the control. The MIC was measured using a microdilution method. The MIC of cefixime against the putative periodotopathogens, as a single use regimen, was relatively lower than that of the other antibiotics. The MIC of cefixime/metronidazole against P. intermedia ChDC KB14, P. nigres- cens ChDC KB50, F. nucleatum ChDC PV-F37, F. nucleatum ChDC F130, and F. nucleatum ChDC F175, as a simultaneous regimen, was lower than that of the other antibiotics. The concentration of cefixime in the crevicular fluid of volunteers who received 250mg every 12 hours for 3 days was 9microgram/ml after 9 hours. In conclusion, cefixime showed good anti- microbial activity in a single treatment or as a combined therapy with amoxicillin, Aug- mentin(R) or metronidazole against 6 periodontopathogens.
