Pseudomyxoma peritonei:18F-FDG PET/CT dual-phase imaging and serum tumor markers among different pathological grades
10.13929/j.issn.1003-3289.2024.06.017
- VernacularTitle:不同病理分级腹膜假黏液瘤:18F-FDG PET/CT双时相显像表现及血清肿瘤标志物水平
- Author:
Li ZHANG
1
;
Bing LI
;
Zhe WEN
;
Guansheng TONG
Author Information
1. 首都医科大学附属北京世纪坛医院核医学科,北京 100038
- Keywords:
pseudomyxoma peritonei;
positron-emission tomography;
tumor markers,biological
- From:
Chinese Journal of Medical Imaging Technology
2024;40(6):880-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate 18F-FDG PET/CT dual-phase imaging features and serum tumor marker levels of pseudomyxoma peritonei(PMP)with different pathological grades.Methods A total of 31 patients with pathologically confirmed PMP originated from appendix were retrospectively analyzed.The tumors were divided into low-grade,high-grade and high-grade with signet-ring cell PMP according to pathological results.18F-FDG PET/CT conventional and delayed imaging manifestations,as well as serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125 and CA 19-9 within 1 month before PET/CT examination were comparatively analyzed among PMP with different pathological grades.Results Among 31 cases,low-grade PMP was found in 14 cases,high-grade PMP in 12 cases while high-grade with signet-ring cell PMP was detected in 5 cases.The maximal standard uptake value(SUVmax)of PMP lesion,the ratio of SUVmax to mean standard uptake value for the liver(SUVmax/SUVliver mean)and PET-peritoneal cancer index(PCI)of low-and high-grade PMP measured on delayed imaging were all higher than those measured on conventional imaging(all P＜0.05).SUVmax,SUVmax/SUVliver mean and PET-PCI of high-grade with sig-ring cell PMP lightly increased on delayed imaging compared with those on conventional imaging,but no significant difference was not(all P＞0.05).No statistical difference of serum CEA,CA 125 and CA 19-9 levels was observed among PMP with different pathological grades.Conclusion 18F-FDG PET/CT dual-phase imaging manifestations of different pathological grades PMP had certain characteristics,while no significant correlation was found between serum tumor marker level and pathological grade of PMP.
