MRI features of H3K27M mutant type and wild type astrocyte differentiated diffuse midline glioma in spinal cord
10.13929/j.issn.1003-3289.2024.06.005
- VernacularTitle:脊髓H3K27M突变型与野生型星形细胞分化弥漫性中线胶质瘤MRI特征
- Author:
Haikuo WANG
1
;
Jie ZHANG
;
Yaowu ZHANG
;
Guanghao ZHENG
;
Junjie LI
;
Yongzhi WANG
;
Wenqing JIA
Author Information
1. 首都医科大学附属北京天坛医院放射科,北京 100070
- Keywords:
spinal cord;
glioma;
mutation;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2024;40(6):815-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe MRI features of H3K27M mutant type and wild type astrocyte differentiated diffuse midline glioma(DMG)in spinal cord.Methods Totally 91 patients with astrocyte differentiation diffuse midline glioma(DMG)in spinal cord confirmed by pathology were retrospectively enrolled and divided into mutant group(n=44)and wild group(n=47)according to H3K27M status.Clinical and MRI manifestations were compared between groups,and logistic regression analysis was used to screen the impact factors of H3K27M mutation.Results The incidence of peritumoral edema and spinal cord cavity in mutant group were lower than those in wild group(both P＜0.05),while no significant difference of other parameters was found between groups(all P＞0.05).All clinical and MRI parameters were included in logistic regression analysis,and the result showed that they were not influencing factors of H3K27M mutation(all P＞0.05).Conclusion The incidence of peritumoral edema and spinal cord cavity in spinal cord H3K27M mutant type astrocyte differentiated DMG were lower than those of wild type,yet not sufficient to be regarded as impact factors for predicting H3K27M mutation of DMG.
