Research Progress in the Role of Advanced Glycation End Products in the Pathogenesis of Sarcopenia
10.3881/j.issn.1000-503X.15521
- VernacularTitle:晚期糖基化终末产物在肌少症发病机制中的作用研究进展
- Author:
Xingyu ZHANG
1
;
Qi GUO
;
Xiaoyu CHEN
Author Information
1. 上海健康医学院康复学院, 上海 201318;天津体育学院运动健康学院 天津市运动生理学与运动医学重点实验室, 天津 301617
- Keywords:
sarcopenia;
advanced glycation end products;
receptor for advanced glycation end products
- From:
Acta Academiae Medicinae Sinicae
2024;46(1):111-118
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is an age-related condition characterized by a decrease in muscle mass and a de-cline in muscle strength.Sarcopenia increases the risk of falls,severely affecting the quality of life of patients,and it may be associated with various age-related chronic diseases.Advanced glycation end products(AGEs)are a class of stable glycation products produced by condensation,rearrangement,cleavage,and oxidative modifica-tion between the free amino groups of proteins,lipids or nucleic acids and the free carbonyl groups of reducing sugars.Studies have revealed associations of AGEs with muscle mass,muscle strength,and sarcopenia.AGEs can lead to hardening of the extracellular matrix of skeletal muscle through glycation cross-linking.The binding of AGEs to receptors induces inflammation and oxidative stress,consequently resulting in decreases in muscle mass and muscle strength.Therefore,AGEs may play a role in the occurrence and development of sarcopenia.This re-view summarizes the role of AGEs in the pathogenesis of sarcopenia,offering theoretical support for probing into the mechanisms underlying sarcopenia.
