Roles of Autophagy and Apoptosis in Sarcopenia
10.3881/j.issn.1000-503X.2018.01.017
- VernacularTitle:自噬和凋亡在肌少症中的研究进展
- Author:
Ge GONG
1
;
Xiang YANG
;
Jian YIN
;
Xinghu ZHANG
;
Yuan ZHANG
;
Wenhui WAN
Author Information
1. 中国人民解放军南京总医院干部病房一科
- Keywords:
sarcopenia;
pathophysiological mechanisms;
autophagy;
apoptosis
- From:
Acta Academiae Medicinae Sinicae
2018;40(1):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is an aged-related progressive and systemic loss of skeletal muscle mass and functions.It may be caused by factors such as exercise,nutrition,genetic factors,endocrine factors,and inflammation.The pathophysiological mechanisms include mitochondrial dysfunction,excessive activation of apoptosis,dysregulation of autophagy,abnormal function of satellite cells,and aggregation of reactive oxygen species.This article summarizes the relationships of autophagy and apoptosis with sarcopenia and discusses the values of autophagy regulation and apoptosis reduction in the management of sarcopenia.
