Advances in gut microbiomes of IgG4-associated diseases

VernacularTitle:IgG4相关性疾病肠道微生物组学的研究进展
Author: Tingting REN ¹ ; Jing LI ; Jianmin MA
Author Information

1. 首都医科大学附属北京同仁医院，北京同仁眼科中心，眼科学与视觉科学北京市重点实验室，北京　100730
Keywords: Immunoglobulin G4-related disease; Gastrointestinal microbiome
From: Journal of Chinese Physician 2024;26(11):1748-1752
CountryChina
Language:Chinese
Abstract: IgG4-associated disease (gG4-RD) is a systemic immune-mediated fibroinflammatory disease that can involve almost all organs and systems, and the main clinical manifestations are enlargement or mass of the affected organs. The typical pathological features of the disease are a large number of lymphocytoplasmic infiltration in the pathological tissue, accompanied by mat fibrosis and obliterated phlebitis, and most patients may have elevated serum IgG4 levels. At present, the specific pathogenesis of the disease is not clear. In recent years, the mechanism of intestinal microbiome dysregulation in the occurrence and development of autoimmune diseases has been gradually clarified. However, the association between the gut microbiome and IgG4-RD is still poorly understood. Therefore, this article will review the progress of intestinal microbiome research of IgG4-RD.