Research progress of cancer related fibroblasts in pancreatic cancer
10.3760/cma.j.cn431274-20230906-00227
- VernacularTitle:胰腺癌中癌症相关成纤维细胞的研究进展
- Author:
Jiacheng LI
1
;
Yongwei WANG
Author Information
1. 哈尔滨医科大学附属第一医院胰胆外科，肝脾外科教育部重点实验室，哈尔滨 150001
- Keywords:
Pancreatic neoplasms;
Cancer-associated fibroblasts
- From:
Journal of Chinese Physician
2024;26(8):1265-1268
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a malignant tumor of digestive system with poor prognosis. It has the characteristics of low early diagnosis rate, low feasible operation rate and low treatment success rate. Most patients are in advanced stage when they are found. Chemotherapy and immunotherapy are important treatments for pancreatic cancer because of its low operative rate. However, the extracellular matrix (ECM) of pancreatic cancer forms a special physical and metabolic barrier, which reduces the effect of chemotherapy and immunotherapy. Cancer associated fibroblast (CAF) are tumor promoting cells in the extracellular matrix and are novel targets for anti-tumor interventions. However, the lack of specific markers and unknown differences between CAF subtypes have hindered relevant clinical trials. This article reviews the origin and functional diversity of CAF, and discusses the clinical progress and treatment strategies of CAF and pancreatic cancer.
