The Skeletal Site-Differential Changes in Bone Mineral Density Following Bone Marrow Transplantation: 3-Year Prospective Study.
10.3346/jkms.2002.17.6.749
- Author:
Won Young LEE
1
;
Moo Il KANG
;
Ki Hyun BAEK
;
Eun Sook OH
;
Ki Won OH
;
Kwang Woo LEE
;
Sun Woo KIM
;
Choon Choo KIM
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. drlwy@samsung.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Bone Marrow Transplantation;
Bone Density
- MeSH:
Adult;
Age Factors;
Anemia, Aplastic/therapy;
*Bone Density;
Bone Marrow Transplantation;
Bone and Bones/drug effects/*metabolism/radiation effects;
Collagen/blood;
Collagen Type I;
Cyclophosphamide/therapeutic use;
Estradiol/blood;
Follicle Stimulating Hormone/blood;
Humans;
Leukemia/therapy;
Luteinizing Hormone/blood;
Middle Aged;
Myelodysplastic Syndromes/therapy;
Peptides/blood;
Prospective Studies;
Time Factors
- From:Journal of Korean Medical Science
2002;17(6):749-754
- CountryRepublic of Korea
- Language:English
-
Abstract:
Loss of bone mass is usually detected after bone marrow transplantation (BMT) during the early post-transplant period. However, little is known about the long-term effects of BMT on bone metabolism. We have prospectively investigated 11 patients undergoing BMT. Bone mineral density (BMD) was measured before BMT, and 1, 2, and 3 yr after BMT. Serum markers of bone turnover were serially measured before BMT and 1, 2, 3, 4, and 12 weeks, 6 months, and 1 yr after BMT. The mean change in the lumbar spine (L2-4) BMD, calculated as the percent change from the baseline to the level at 1, 2, and 3 yr was -4.7% (NS), -1.1% (NS), and +6.4% (p<0.05), respectively. The mean change in the total proximal femur BMD from the baseline to the level at 1, 2, and 3 yr was -8.5% (p<0.01), -8.7% (p<0.05) and -5.6% (p<0.05), respectively. In summary, there was little decline in lumbar BMD at 1 yr following BMT and gradual recovery until 3 yr. In contrast, femoral BMD decreased much more than the lumbar area at 1 yr and did not recover until 3 yr. The mechanism of skeletal site-selective differences in the changes of BMD needs to be elucidated.
