Efficacy of interferon α-2b combined with chlorquinaldol-promestriene on cervical intraepithelial neoplasia patients after loop electrosurgical excisional procedure
10.12173/j.issn.1008-049X.202404148
- VernacularTitle:干扰素α-2b联合氯喹那多/普罗雌烯对宫颈上皮内瘤变Leep术后的疗效观察
- Author:
Yanyan SU
1
;
Hu YANG
Author Information
1. 北京市顺义区妇幼保健院妇科(北京 101300)
- Keywords:
Cervical intraepithelial neoplasia;
Interferon α-2b;
Chlorquinaldol-promestriene;
Loop electrosurgical excisional procedure
- From:
China Pharmacist
2024;27(6):1041-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of human interferonα-2b(INF α-2b)combined with chlorquinaldol-promestriene(CP)in treating cervical intraepithelial neoplasia(CIN)following a loop electrosurgical excision procedure(LEEP).Methods Clinical data of CIN patients treated at the Shunyi District Maternal and Child Health Hospital in Beijing from September 2022 to September 2023 were retrospectively collected.Patients were divided into two groups based on their postoperative medication regimen:the interferon group(INF α-2b)and the combination group(INF α-2b combined with CP).Changes in inflammatory factors[C-reactive protein(CRP)and serum amyloid A(SAA)]and immune function factors[CD4+,CD8+,and CD4+/CD8+ratios]were compared before and after 3 months of the treatment.Clinical efficacy[treatment response rate,HPV clearance rate,and six-month recurrence rate]and complications were also assessed.Results A total of 106 CIN patients were included,with 68 in the interferon group and 38 in the combination group.Before treatment,there were no significant differences in serum CRP,SAA levels,blood CD4+lymphocyte ratio,CD8+lymphocyte ratio,and CD4+/CD8+ratio between the two groups(P＞0.05).After treatment,both groups showed significant decreases in serum CRP,SAA levels,and blood CD8+lymphocyte ratio(P＜0.05),and significant increases in blood CD4+lymphocyte ratio and CD4+/CD8+ratio(P＜0.05),compared with before treatment.In addition,the combination group had significantly lower serum CRP,SAA levels,and blood CD8+lymphocyte ratio,and significantly higher blood CD4+lymphocyte ratio and CD4+/CD8+ratio than the interferon group.The effective rate and HR-HPV clearance rate in the combination group were significantly higher than those in the interferon group.There was no significant difference in the six-month recurrence rate(P＜0.05)or the postoperative complication rate(P＞0.05).Conclusion INF α-2b combined with CP can improve inflammation levels,immune function,clinical efficacy,and HPV clearance rate in CIN patients after LEEP but not affect the six-month recurrence rate or complication rate.
