Comparative study of dry and wet extrusion granulation of Five-Juice Decoction granules
10.12173/j.issn.1008-049X.202312149
- VernacularTitle:五汁饮颗粒干法制粒与湿法挤压制粒比较研究
- Author:
Siyi WANG
1
;
Yani XIE
;
Guangyu CHEN
Author Information
1. 湖南中医药大学药食同源功能性食品工程技术研究中心(长沙 410208);湖南中医药大学中医心肺病证辨证与药膳食疗重点研究室(长沙 410208)
- Keywords:
Five-Juice Decoction;
Granules;
Dry granulation;
Wet extrusion granulation;
Granule yield;
Box-Behnken design-response
- From:
China Pharmacist
2024;27(5):756-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the dry granulation technology of Five-Juice Decoction granules.Methods The granule yield was used as the evaluation index to optimize the dry granulation process parameters of Five-Juice Decoction granules by Box-Behnken design-response surface design test.The granule yield,repose angle,dissolve time,humidity absorption rate and particle roundness were used as evaluation indexes,and three batches of validation tests were conducted to compare the difference between the dry granules optimized in this study and the wet extruded granules optimized in previous studies.Results The optimal technological parameters for dry granulation of Five-Juice Decoction granules were as follows:the pressure of the hydraulic system was 3.5 Mpa,the wheel speed was 5.4 r/min,the feeding speed was 7.2 r/min,and the granulation speed was 80 r/min.The technological parameters of wet granulation were as follows:the soft material was made from 90%ethanol,extruded through a 10-mesh sieve for granulation,and dried under reduced pressure at 50 °C to a moisture content of<5%.The granule yield and humidity absorption rate of dry granulation were better than those of wet extruded granules.Conclusion Dry granulation process is better than wet extrusion process of Five-Juice Decoction granules.The optimized dry granulation process is stable and feasible,which can provide a reference for industrial production.
