Research and development of new quantitative packaging device and its application to preparation of national pharmaceutical standard substances
10.19778/j.chp.2024.04.018
- VernacularTitle:新型定量分装装置的研发及其在国家药品标准物质制备中的应用
- Author:
Li WANG
1
;
Zongge ZHAO
;
Jing YAO
;
Qi ZHANG
;
Yajun WANG
;
Mingli LIU
Author Information
1. 中国食品药品检定研究院,北京 102629
- Keywords:
national drug standard substances;
powder;
quantitative packaging;
adjustable loading;
improvement of production efficiency
- From:
Drug Standards of China
2024;25(4):430-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the dispensing method of national drug standard substances and develop a novel adjustable quantitative dispensing device for improving dispensing efficiency and production quality.Methods:Stain-less steel was used to fabricate an adjustable volume tank and a matching scraper for dispensing powder samples of fixed volume.Results:31 types of uniform powder samples,including chemicals and pharmaceutical excipients,were dispensed using the dispensing device.It showed a small test fluctuation range,high accuracy,and consistent effectiveness among different samples.The dispensing efficiency was improved by 147％compared to the conventional method of single-weight dispensing using a balance.Conclusion:The device can significantly reduce dispensing time,increase production efficiency,and meet the dispensing specifications for drug standard substances,which brings remarkable convenience and value to the production and preparation of drug standard substances.
