Research progress in regulatory mechanism and traditional Chinese medicine intervention of circular RNA for coronary atherosclerotic heart disease
- VernacularTitle:环状RNA调控冠心病的机制及中药干预研究进展
- Author:
Lan-Tian HU
1
;
Xue-Na XIE
;
Yu-Ying WANG
;
Mei LIU
;
Hong-Ai GUO
;
Rong YUAN
;
Qi-Qi XIN
;
Yu MIAO
;
Wei-Hong CONG
Author Information
- Keywords: non-coding RNA; circRNA; coronary heart dis-ease; atherosclerosis; myocardial infarction; heart failure
- From: Chinese Pharmacological Bulletin 2024;40(11):2014-2019
- CountryChina
- Language:Chinese
- Abstract: Coronary atherosclerotic heart disease(CHD)is an ischemic cardiovascular condition caused by the narrowing or blockage of the vascular lumen due to coronary atherosclerosis.Clinically,it presents as angina pectoris,heart failure,or sud-den cardiac death,and stands as one of the primary causes of mortality among both urban and rural populations in China.Cir-cRNA,classified as non-coding RNAs,can function as upstream regulatory molecules for miRNA or RNA-binding proteins.They actively participate in various pathological processes associated with CHD,including endothelial cell dysfunction,smooth mus-cle cell migration,macrophage-derived foam cell formation,an-giogenesis,myocardial injury,and repair,as well as post-in-farction heart failure.The expression pattern of these molecules is highly specific to the illness and tissue,indicating their poten-tial as therapeutic targets for disease management and as biomar-kers.Furthermore,they also open up new avenues for drug tar-get development in the field of traditional Chinese medicine.This article aims to provide an overview of the recent research progress on circRNA in the regulation of coronary heart disease,as well as the mechanisms involved in traditional Chinese medi-cine.It serves as a valuable reference for future research on cor-onary heart disease.
