Effect of safflower yellow on SCOP-induced cognitive impairment in mice based on BDNF/TrkB/CREB pathway
- VernacularTitle:红花黄色素对SCOP诱导小鼠认知功能损伤的保护作用
- Author:
Yan-Qiang QI
1
;
Hong-Xia YE
;
Yan-You WANG
;
Xia LI
;
Ying-Xi HE
;
Hui TIAN
;
Le LI
;
Yan-Li HU
Author Information
- Keywords: Alzheimer's disease; safflower yellow pig-ment; scopolamine hydrobromide; cholinergic system; BDNF/TrkB/CREB pathway; synaptic plasticity
- From: Chinese Pharmacological Bulletin 2024;40(10):1858-1865
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effect of safflower yellow on the learning and memory of scopolamine hydrobromide-induced memory impairment model mice.Methods 6-month-old C57BL/6J mice were randomly divided into the control group,model group,SY high-dose group,SY medium-dose group,SY low-dose group,and Huperzine-A group(12 mice in each group).SCOP was used to establish a memory impair-ment model,the spatial learning,memory and cognitive ability of mice with memory impairment were evaluated by behavioral experiments,the function of the choliner-gic nervous system in the cortex of mice was measured by ELISA kit,the pathological changes of brain tissue were observed by Nissl staining,and the expression of synaptic plasticity and BDNF/TrkB/CREB pathway re-lated proteins in the cortical and hippocampus of mice in each group was detected by Western blot.Results Compared with the model group,the learning and mem-ory ability of the mice in each administration group was improved.The neurons in the hippocampus and corti-cal were neatly arranged,the cell morphology tended to be complete,and the number of normal neurons in-creased.The function of the cortical cholinergic nerv-ous system was significantly improved,the expression of synaptic plasticity-related proteins in brain tissue was increased,and the BDNF/TrkB/CREB signaling path-way was activated.Conclusions SY can significantly improve the learning and memory ability of mice with SCOP-induced memory impairment,and its mechanism may play a neuroprotective role by improving choliner-gic nervous system function,activating BDNF/TrkB/CREB signaling pathway,regulating synaptic plasticity,and reduces neuronal damage.
