ER-mitochondrial interaction in Parkinson's disease
- VernacularTitle:内质网-线粒体互作在帕金森病中的研究进展
- Author:
Xiao-Min XU
1
;
Shu-Min LIU
;
Ying ZHANG
;
Xin JIANG
;
Peng XU
;
Fang LU
Author Information
- Keywords: ER-mitochondrial interaction; Parkinson's disease; site of contact between ER and mitochondria; mitochondria; ER
- From: Chinese Pharmacological Bulletin 2024;40(10):1819-1823
- CountryChina
- Language:Chinese
- Abstract: The interaction between organelles is the focus of re-search in neural development.The contact site of endoplasmic reticulum and mitochondria is the focus of Parkinson's disease(PD)in recent years.The research shows that mitochondria,endoplasmic reticulum(ER),lysosome and other organelles play an important role in neurogenesis.Specifically,metabolic turnover,reactive oxygen species production,mitochondrial dy-namics,mitochondrial autophagy,mitochondria-mediated apop-tosis,and interactions between mitochondria and the ER all play a role in neurogenesis.In PD,abnormal ER-mitochondrial inter-action can affect mitochondrial calcium overload,mitochondrial fission and fusion imbalance,and lipid homeostasis disorder.Therefore,here we review the recent progress in the main regu-latory mechanisms of ER-mitochondrial interaction and address the effects of abnormal ER-mitochondrial interactions on PD.
