Research progress on regulation and mechanism of active components of traditional Chinese medicine on keratinocyte apoptosis in psoriasis
- VernacularTitle:中药有效成分对银屑病角质形成细胞凋亡的调控作用及机制的研究进展
- Author:
Shuang CAO
1
;
Yue-Peng AN
;
Shu-Min LIU
;
Su-Qing YANG
Author Information
- Keywords: keratinocytes; apoptosis; psoriasis; active compo-nents of traditional Chinese medicine; mechanism; research pro-gress
- From: Chinese Pharmacological Bulletin 2024;40(9):1616-1621
- CountryChina
- Language:Chinese
- Abstract: Apoptosis is a process of programmed cell death,which has the function of maintaining skin balance.In psoriasis,the disturbance of apoptosis is characterized by abnormal prolif-eration of keratinocytes.Traditional Chinese medicine(TCM)has a regulatory effect on keratinocyte apoptosis,which can in-hibit the excessive proliferation of psoriasis epidermis,promote normal epidermal differentiation,and maintain epidermal homeo-stasis.It has the advantages of fewer adverse reactions and multi-targets.Therefore,this article summarizes and analyzes the specific mechanism of various active ingredients of TCM to in-duce the apoptosis of psoriasis keratinocytes by interfering with related factors and signaling pathways,hoping to provide a refer-ence for the treatment of psoriasis with TCM.
