Research progress of PK2 in treatment of cardio-cerebrovascular and neurodegenerative diseases
10.12360/CPB202301061
- VernacularTitle:前动力蛋白受体2在心脑血管及神经退行性疾病治疗中的研究进展
- Author:
Feng LI
1
;
Jian-Hua FU
;
Lu ZHANG
;
Ming-Jiang YAO
Author Information
1. 中国中医科学院西苑医院基础医学研究所
- Keywords:
PK2;
cardiovascular diseases;
cerebrovascular dis-eases;
neurodegenerative diseases;
mechanism of action
- From:
Chinese Pharmacological Bulletin
2024;40(8):1401-1407
- CountryChina
- Language:Chinese
-
Abstract:
Cardio-cerebrovascular and neurodegenerative diseases are diseases of high-incidence diseases among middle-aged and elderly people,with high disability and mortality rates,which se-riously threaten human health.PK2 is a newly discovered secre-ted protein that plays an important role in many physiological and pathological processes by binding to its receptor PKR1 or 2.Numerous studies related to PK2/PKRs have shown that this sig-naling pathway also plays a very important role in the occurrence and development of cardiovascular,cerebrovascular and neuro-degenerative diseases,and through exploring the connection be-tween them,PK2/PKRs may become a new target for the clini-cal treatment of these diseases.
