Research progresses of endogenous vascular calcification inhibitor BMP-7
- VernacularTitle:血管钙化抑制因子BMP-7的研究进展
- Author:
Xin ZHOU
1
;
Lu XING
;
Peng-Quan LI
;
Dong ZHAO
;
Hai-Qing CHU
;
Chun-Xia HE
;
Wei QIN
;
Hui-Jin LI
;
Jia FU
;
Ye ZHANG
;
Li XIAO
;
Hui-Ling CAO
Author Information
- Keywords: BMP-7; vascular calcification; bone formation; vascular smooth muscle cells; secreted proteins; molecular mechanism
- From: Chinese Pharmacological Bulletin 2024;40(7):1226-1230
- CountryChina
- Language:Chinese
- Abstract: Vascular calcification is a highly regulated process of ectopic calcification in cardiovascular system while no effective intervention can be clinically performed up to date.As vascular calcification undergoes a common regulatory mechanism within bone formation,bone morphogenetic protein 7(BMP-7)main-tains contractile phenotype of vascular smooth muscle cells and further inhibits vascular calcification via promoting the process of osteoblast differentiation,reducing ectopic calcification pressure by increasing bone formation and reducing bone resorption.This work systematically reviews the role of BMP-7 in vascular calcifi-cation and the possible mechanism,and their current clinical application as well.The current proceedings may help develope early diagnostic strategy and therapeutic treatment with BMP-7 as a new molecular marker and potential drug target.The expec-tation could achieve early prevention and intervention of vascular calcification and improve poor prognosis on patients.
