m6A modification regulates drug-metabolizing enzymes and drug transporters
- VernacularTitle:m6A修饰对药物代谢酶和药物转运体的调控作用
- Author:
Shi-Yu ZHAO
1
;
Shuai-Bing LIU
;
Yue-Qin WANG
;
Xin TIAN
Author Information
- Keywords: RNA methylation; m6A modification; drug-metab-olizing enzymes; drug transporters; regulatory mechanism; re-search progress
- From: Chinese Pharmacological Bulletin 2024;40(7):1221-1225
- CountryChina
- Language:Chinese
- Abstract: N6-methyladenosine(m6A)is the most abundant modification of RNA methylation,dynamically regulated by"writer"and"eraser",regulating the expression of target genes by modulating key biological processes such as mRNA splicing,stability,and translation,after being recognized and combined by"reader".Recent studies have revealed that m6A modifica-tion can regulate the expression of drug-metabolizing enzymes and transporters,consequently affecting the body's drug meta-bolic rate or intracellular drug concentrations,and ultimately in-fluencing therapeutic outcomes.This article reviews the research progress of the molecular mechanism of m6A modification regula-ting drug-metabolizing enzymes and transporters,so as to pro-vide a new idea for rational and personalized clinicaldrug use.
