Research progress on extracellular vesicles in knee osteoarthritis
- VernacularTitle:外泌体在膝关节骨性关节炎中的研究进展
- Author:
Xi XIE
1
;
Ye SHI
;
Han-Qing DENG
;
Xu-Xia YANG
;
Xu-Fang TAN
;
Hong-Jun LOU
;
Ling LI
;
Xi GAO
Author Information
- Keywords: knee osteoarthritis; extracellular vesicles; mesen-chymal stem cells; miRNA; research progress; review
- From: Chinese Pharmacological Bulletin 2024;40(6):1020-1024
- CountryChina
- Language:Chinese
- Abstract: The incidence of knee osteoarthritis(KOA)is in-creasing year by year,seriously affecting patients'health.Mes-enchymal stem cells are multipotent cells with multiple differen-tiation functions.The extracellular vesicles released by these cells can carry various"cargo"to corresponding cells and tis-sues,exerting biological functions.They have shown great clini-cal potential in the treatment of KOA.This study reviews the therapeutic effects and mechanisms of extracellular vesicles se-creted by mesenchymal stem cells from different tissues such as bone marrow,adipose tissue,and synovium in KOA.It is found that miRNA is an important biological component in exerting therapeutic effects.The study also discusses the research pro-gress of engineered extracellular vesicles in KOA,pointing out the current challenges in clinical application,such as standard-ized acquisition of extracellular vesicles and difficulties in targe-ted action,aiming to provide a certain reference for the basic re-search and clinical application of extracellular vesicle therapy for KOA.
