Progress in research on mitochondria-associated endoplasmic reticulum membranes and their role in myocardial ischemia-reperfusion injury
- VernacularTitle:线粒体相关内质网膜及其在心肌缺血/再灌注损伤中作用的研究进展
- Author:
Shuang HU
1
;
Jing WEN
;
Xiao-Di FAN
;
Peng LI
Author Information
- Keywords: mitochondria-associated endoplasmic reticulum membranes; myocardial ischemia reperfusion injury; organelle interaction; ER-mitochondria microdomains; calcium signaling; endoplasmic reticulum-mitochondria contact sites
- From: Chinese Pharmacological Bulletin 2024;40(6):1001-1006
- CountryChina
- Language:Chinese
- Abstract: Traditionally,organelles are regarded as isolated units having specific ingredients and structures and functioning sepa-rately.Accumulating studies have showed that neighboring dif-ferent organelles can form membrane contacts through interac-tions of protein-protein or protein-lipid.Mitochondria-associated endoplasmic reticulum membranes,i.e.MAMs,contact these two organelles,and enrich a variety of proteins,which strictly regulate the material exchange between the endoplasmic reticu-lum and the mitochondria and the functions of them.In myocar-dial ischemia-reperfusion injury(MIRI),MAMs play an ex-tremely important role,which controls a series of key pathologi-cal processes,such as mitochondrial division,mitochondrial au-tophagy,oxidative stress,and calcium overload,etc.,thus be-ing a promising and important new therapeutic target.This paper detailedly reviews the progress in the research on MAMs'struc-ture and function and its role in MIRI.
