Advances of studies on myelin regeneration by GABAergic networks in neurodevelopment and brain diseases
- VernacularTitle:GABAergic网络在神经发育和脑疾病中对髓鞘再生的研究进展
- Author:
Xiao-Di FAN
1
;
Ye-Hao ZHANG
;
Jian-Xun LIU
Author Information
- Keywords: γ-aminobutyric acid; GABAergic networks; oligo-dendrocytes; interneurons; myelination; neurodevelopment and diseases
- From: Chinese Pharmacological Bulletin 2024;40(5):801-806
- CountryChina
- Language:Chinese
- Abstract: Differentiation of oligodendrocyte precursor cells(OPCs)into mature oligodendrocytes(OLs)is a key event for axonal myelination in the central nervous system(CNS).Stud-ies have shown that neurotransmitters like GABA,GABAergic synapses and network regulation play important roles in the pro-liferation,differentiation,migration and myelination of oligoden-drocytes.Therefore,the paper reviews recent studies on the bio-logical functions of GABA and its receptors in oligodendrocyte lineages,the interaction between GABAergic interneurons and OPCs,the network regulation of GABAergic interneurons media-ting myelination,and potential future drug candidates.Based on this,understanding the mechanisms that control OLs differentia-tion is essential for identifying therapeutic strategies that promote myelin repair,and research surrounding GABAergic may have potential implications for the development of novel repair thera-pies for demyelinating diseases.
