Current status and progress of Parkinson disease treatment
10.3760/cma.j.cn371468-20240512-00220
- VernacularTitle:帕金森病治疗现状及新进展
- Author:
Qiuxia CHEN
1
;
Mengyan LI
;
Ting WANG
Author Information
1. 广东医科大学第一临床医学院，湛江 524002
- Keywords:
Parkinson disease;
Drug therapy;
Non-drug therapy;
New technique;
Progress
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(9):807-812
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson disease (PD) is a chronic progressive neurodegenerative disorder that typically leads to motor impairments (such as increased muscle tone, resting tremors, bradykinesia and postural instability) and various non-motor symptoms (including sleep disturbances, anxiety, depression, cognitive impairments and autonomic nervous system dysfunction). Currently, symptomatic treatment primarily relies on medication, but non-pharmacological approaches are also crucial, such as psychological interventions, rehabilitation therapies, neurostimulation techniques, biosensors and monitoring technologies. However, these are all symptomatic treatments, as PD cannot be completely cured at present and there are many limitations. Nevertheless, some promising new therapies such as optogenetics, drug delivery systems, stem cell therapy, gene therapy, immunotherapy, neuroprotection, and interventions to improve gut microbiota imbalance offer hope for alleviating PD symptoms and potentially making a cure for PD achievable in the future. This article provides an overview of the current status and recent advancements in both pharmacological and non-pharmacological treatments for Parkinson disease, as well as prospects for future promising therapeutic technologies.
