Value of Two-dimensional Speckle Tracking Imaging on Assessment of Right Ventricular Function in Patients With Fabry Disease
10.3969/j.issn.1000-3614.2024.10.007
- VernacularTitle:二维斑点追踪超声心动图技术对法布雷病患者右心室功能及应变特征的评估
- Author:
Han WANG
1
;
Lin LIU
;
Yawen ZHAO
;
Wei ZHANG
;
Yang LI
;
Ying YANG
;
Wei MA
Author Information
1. 北京大学第一医院 心内科,北京 100034;北京大学第一医院 心血管疾病研究所 超声心动图中心实验室,北京 100034
- Keywords:
Fabry disease;
echocardiography;
speckle tracking imaging;
myocardial strain;
right ventricular function
- From:
Chinese Circulation Journal
2024;39(10):997-1002
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To explore the clinical value of two-dimensional speckle tracking echocardiography(STE)on evaluating right ventricular function in patients with Fabry disease(FD). Methods:From August 2014 to June 2023,57 patients with FD and 57 age-(±2 year)and sex-matched healthy controls were included in this study.Clinical characteristics,echocardiographic parameters and right ventricular strain parameters were compared between the two groups.According to the left ventricular mass index(LVMI),FD patients were further divided into the left ventricular hypertrophy(LVH)group(n=22,men:LVMI≥115 g/m2,women:LVMI≥95 g/m2)and the non-LVH(n=35,men:LVMI<115 g/m2,women:LVMI<95 g/m2)group,the association between right ventricular strain and LVH in FD patients was analyzed. Results:(1)The brain natriuretic peptide(BNP)level was higher,heart rate and estimate glomerular filtration rate(eGFR)were lower in the FD group than in healthy control group(all P<0.05).Interventricular septum(IVS)and left ventricular posterior wall(LVPW)thickness as well as left ventricular mass index(LVMI)and right ventricular free wall(RVFW)thickness were significantly higher in FD group than in healthy control group(all P<0.05).(2)Subgroup analysis showed that the age,systolic blood pressure,BNP,LVMI and RVFW thickness were significantly higher,while eGFR was lower in the LVH group than in the non-LVH group(all P<0.05).(3)The left ventricular global longitudinal strain(LVGLS),right ventricular global longitudinal strain(RVGLS),right ventricular free wall strain(RVFWS),RVFWS at basal,middle and apical segment were lower in FD patients than in healthy controls(all P<0.05).There was no significant difference in right ventricular strain difference value(ΔRV)between the FD group and controls(P>0.05).(4)In the LVH group,LVGLS and RVGLS were significantly declined and ΔRV increased(all P<0.05),while RVFWS and all three segments preserved compared with the non-LVH group(all P>0.05). Conclusions:Myocardial strain analysis is valuable on the assessment of global and regional myocardial work in FD patients.RVGLS and RVFWS are reduced in FD patients.RVGLS is decreased in the LVH patients,while RVFWS is preserved in FD patients.
