Identification of NUF2 expression pattern and its prognostic value of in breast cancer
10.3969/j.issn.1009-9905.2024.09.006
- VernacularTitle:NUF2在乳腺癌中的表达模式及其预后价值
- Author:
Xue-Zhi LIU
1
;
Bao-Ping ZHU
;
Ying-De LI
;
Qian CHEN
Author Information
1. 寿光市人民医院 普外科(山东 潍坊 262700)
- Keywords:
Breast cancer;
NUF2;
Prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(9):699-703
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression pattern and prognostic value of NUF2(Ndc80 kinetochore complex component)in breast cancer(BC).Methods:In the present study,the trancriptional level and survival information of NUF2 was analyzed by ONCOMINE dataset,bc-GenExMiner,Kaplan-Meier Plotter and TCGA.Results:NUF2 was highly expressed in BC com-pared with normal samples(P＜0.05).In addition,the BC patients younger than 51 years old(P＜0.0001),nodal metastasis(P=0.0168),with basal-like BC(P＜0.0001),orestrogen receptor(ER)-negative(P＜0.0001),progesterone receptor(PR)-negative(P＜0.0001),human epidermal growth factor receptor-2(HER2)-positive(P＜0.0001)and triple-negative BC(P＜0.0001)pathological clas-sification have a higher transcriptional level of NUF2.Survival analysis indicated that patients with low expression level of NUF2 have a better relapse-free survival(RFS,HR=1.63,P＜0.0001).Fur-ther anaysis revealed that the NUF2 expression was negatively related to the RFS of BC patients with ER-positive or PR-positive or HER2-negative pathological classification(HR=2.40,P=0.0015).Conclusion:NUF2 play an important role in BC and can be a potential prognostic bio-marker for ER-positive or PR-positive or HER2-negative BC patients.
