Network pharmacology-based strategy for predicting therapy targets of apigenin on thyroid carcinoma
10.3969/j.issn.1009-9905.2024.08.002
- VernacularTitle:基于网络药理学研究芹菜素治疗甲状腺癌的潜在靶点
- Author:
Shu-Bin LIANG
1
;
Zhen LI
;
Sheng-Nan WANG
;
Yun-Hui WANG
Author Information
1. 青岛大学附属烟台毓璜顶医院 普通外科(山东 烟台 264003)
- Keywords:
Thyroid carcinoma;
Apigenin;
Network pharmacology
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(8):594-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the potential therapeutic targets of apigenin in the treat-ment of thyroid carcinoma by network pharmacology.Methods:The targets of apigenin were screened by HIT(High Throughput),Binding Database,SEA(Similarity Ensemble Approach),STITCH(Search Tool for Interactions of Chemicals),PharmMapper.Thyroid carcinoma related targets were mined from TTD(Therapeutic Target Database),DrugBank,CTD(Comparative Toxicogenomics Da-tabase),DisGeNET databases.The String database and Cytoscape 3.2.1 software were used to identify and screen out the hub targets of apigenin for thyroid carcinoma.The David database was used for Gene Ontology(GO)enrichment and KEGG signal pathway enrichment analysis of hub tar-gets.Finally,the Kaplan-Meier Plotter database was used to analyze the prognosis of hub targets.Results:175potential targets of apigenin and 168 potential targets related to thyroid carcinoma were included.37 overlapping targets of apigenin and thyroid carcinoma were obtained.32 hub targets were finally selected by network topology analysis.These hub targets of apigenin in the treatment of thyroid carcinoma were mainly enriched in involving HIF-1 signaling pathway,path-ways in cancer,etc.Finally,8 targets were screened to be associated with the survival and prog-nosis of thyroid carcinoma patients.Conclusion:Our study suggested that ALB,CCNA2,CCND1,CYP2C19,TERT,TTR,BCL2,CBR1 might be potential therapeutic targets for apigenin in the treatment of thyroid carcinoma.
