Prognostic value of AFP in gastric cancer and its association with immune characteristics
10.3969/j.issn.1009-9905.2024.07.005
- VernacularTitle:甲胎蛋白在胃癌中的预后价值及与免疫特征的相关性
- Author:
Qing-Qing XU
1
;
Huan JIN
Author Information
1. 黄石市中心医院(湖北理工学院附属医院)病理科(湖北 黄石 435000)
- Keywords:
Stomach neoplasms;
Alpha-fetoprotein;
Immunohistochemistry;
Immune check point;
Bioinformatics analysis
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(7):528-532
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and prognosis of alpha-fetoprotein(AFP)in gastric cancer and its correlation with immune characteristics.Methods:Immunohisto-chemistry was used to detect the expression of AFP in gastric cancer tissues,adjacent tissues,and adenoma tissues.The correlation between AFP expression and clinicopathological features of gastric cancer and prognosis was analyzed.The potential mechanism of AFP in the progression of gastric cancer was analyzed by gene enrichment analysis.Results:AFP expression in gastric cancer tissues was significantly high expression in 37 cases and significantly low expression in 26 cases.AFP expression in gastric cancer tissues was significantly higher than that in paracan-cerous tissue and adenoma tissue.The proportions of lymph node metastasis and vascular inva-sion in the AFP high expression group were significantly higher than those in the low expression group(x2=2.020,6.293,P＜0.05).The results of prognosis analysis showed that the hospital stay in the high AFP expression group was significantly longer than that in the low AFP expression group(t=3.816,P＜0.05),and the overall survival was significantly lower than that in the low AFP expression group(t=6.165,P＜0.05).AFP was highly expressed in gastric cancer and mainly con-centrated in epithelial-mesenchymal transformation(EMT),which was positively correlated with SNAIL1,STAT5,and KRAS(r=0.550,0.429,0.221,P＜0.05).It was positively correlated with PD-L1,PD-L2,LAG3,CTLA4,TIM3 and other immunotherapy checkpoint genes(r=0.373,0.643,0.233,0.271,0.620,P＜0.05).Conclusion:AFP expression is up-regulated in gastric cancer,which may promote the development of gastric cancer through EMT and immune checkpoint.
