Prognostic value of tumor mutation burden in pancreatic neuroendocrine tumours
10.3969/j.issn.1009-9905.2024.07.004
- VernacularTitle:肿瘤突变负荷在胰腺神经内分泌肿瘤中的预后价值
- Author:
Gang LI
1
;
Qi-Sen YAN
;
Yong-Zhi FAN
Author Information
1. 庆云县人民医院 普通外科二病区(山东 德州 253700)
- Keywords:
Pancreatic neuroendocrine tumours;
Tumor mutation burden;
Prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(7):522-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic value of tumor mutation burden(TMB)in pancreatic neuroendocrine tumours(PanNETs).Methods:Data of 96 PanNETs patients was in-cluded in the study and cut-off value of TMB was determined according to the time dependent re-ceiver operator characteristic(ROC)curve and area under the curve(AUC).Logistic regression analysis was used to determine the clinical and pathological features associated with TMB.Cox re-gression analysis was used to detect the correlation between TMB and the overall survival time(OS)of patients.Kaplan-Meier method was used to construct the survival curve.Results:Ac-cording to the time dependent ROC curve and AUC,the optimal truncation value of TMB was deter-mined to be 0.6 mut/Mb.Logistic regression analysis indicated that high TMB was independently correlated with age[OR=1.126(1.057-11.199),P＜0.001]and extrapancreatic spread[OR=15.931(2.228-113.892),P=0.006].Kaplan-Meier curve showed that patients with high TMB had a poor OS[HR=5.042(1.41917.917),P=0.012].Multivariate Cox regression analysis indicated that TMB was an independent prognostic factor of PanNETs[HR=7.578(1.409-40.744),P=0.018].Conclusion:TMB is independently correlated with age and extrapancreatic spread,and is an independent prog-nostic factor for PanNETs patients and PanNETs patients with high TMB have a poorer prognosis.
