Research progress on the role of mitochondrial dynamics disorder in sepsis-associated acute kidney injury

VernacularTitle:线粒体动力学紊乱在脓毒症相关性急性肾损伤发病机制中的作用研究进展
Author: Zhu LI ¹ ; Lili TANG ; Jie ZHANG ; Dongrui HE ; Jianglu TAN ; Xiaoyue LI
Author Information

1. 遵义医科大学第五附属（珠海）医院急诊科，广东珠海　519000
Keywords: Sepsis; Sepsis-associated acute kidneyinjury; Mitochondrial dynamics disorder
From: Chinese Critical Care Medicine 2024;36(10):1117-1120
CountryChina
Language:Chinese
Abstract: Sepsis is a life-threatening organ dysfunction caused by the host's uncontrolled response to infection, and is one of the main causes of death in critically ill patients. Sepsis-associated acute kidney injury (SA-AKI) is associated with the poor prognosis of sepsis patients, and its pathogenesis is complex and still unclear to this day.Mitochondrial dynamics is crucial for maintaining the normal morphology, quantity, number and function of mitochondria, which is a new research hotspot in recent years. Mitochondrial dynamics disorder is involved in the occurrence and development of SA-AKI by regulating renal tubular dysfunction, which is expected to become new therapeutic targets. Deeply exploring the role of mitochondrial dynamic disorders in the pathogenesis of SA-AKI will help to find more effective treatment methods, thereby improving the success rate of rescue in SA-AKI patients.