Research progress of the role of non-coding RNA in hyperoxia-induced acute lung injury
10.3760/cma.j.cn121430-20230809-00597
- VernacularTitle:非编码RNA在高氧性急性肺损伤中作用的研究进展
- Author:
Taishan WANG
1
;
Guizhen YIN
;
Guoyue LIU
Author Information
1. 遵义医科大学第二附属医院重症医学科，贵州遵义 563000
- Keywords:
Hyperoxia-induced acute lung injury;
Non-coding RNA;
Acute respiratory distress syndrome;
TypeⅡ alveolar epithelial cell;
Apoptosis
- From:
Chinese Critical Care Medicine
2024;36(4):430-434
- CountryChina
- Language:Chinese
-
Abstract:
Hyperoxia-induced acute lung injury (HALI) is an important complication of clinical oxygen therapy, which is mainly characterized by acute respiratory distress syndrome (ARDS) in adults and broncho-pulmonary dysplasia (BPD) in infants. HALI seriously affects the prognosis and quality of life of patients, so it has received more and more attention. However, the pathogenesis of HALI is complex and unclear, and there is no clear treatment method at present. Non-coding RNA (ncRNA) is an important type of functional RNA transcriptome. Due to the lack of effective open reading frame, ncRNA does not have the function of coding proteins. However, ncRNA can still regulate gene expression at multiple levels and affect the occurrence and development of many diseases. In recent years, a large number of in vitro and in vivo studies have shown that ncRNA is involved in the pathogenesis of HALI and is of great significance. This article reviews the expression and significance of ncRNA in HALI, in order to provide new diagnosis and treatment ideas for the prevention and treatment of HALI.
