Changes in baseline normal neutrophil/lymphocyte ratio and the risk of diabetic peripheral neuropathy
10.3969/j.issn.1006-6187.2024.11.004
- VernacularTitle:基线正常中性粒细胞/淋巴细胞比值变化与糖尿病周围神经病变患病风险相关性的研究
- Author:
Hong LIU
1
;
Xiaolan FENG
;
Si YOU
Author Information
1. 621900 绵阳,四川省科学城医院内分泌科
- Keywords:
Neutrophil;
Lymphocyte;
Diabetic peripheral neuropathy;
Nerve conduction velocity
- From:
Chinese Journal of Diabetes
2024;32(11):821-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between baseline normal neutrophil/lymphocyte ratio(NLR)changes and the risk of diabetic peripheral neuropathy(DPN).Methods A total of 200 type 2 diabetes mellitus(T2DM)patients admitted to our hospital from November 2016 to November 2021 were retrospectively selected.They were divided into DPN group(87 cases)and T2DM group(113 cases)according to whether peripheral neuropathy was present.In the verification group,there were 26 T2DM patients combined with DPN.Multivariate Cox regression analysis was used to analyze the risk factors affecting DPN.A homogram prediction model was constructed.Receiver operating characteristic(ROC)curve and calibration curve were used to evaluate the predictive efficiency of the model.All patients were followed up for 1 year to compare the effects of changes in NLR on the risk of new DPN and nerve conduction velocity.Results DM duration(HR 2.358,95%CI 1.754～3.658),triglyceride(HR 3.085,95%CI 2.454～6.778),baseline NLR(HR 3.145,95%CI 1.466～5.632)were risk factors for DPN.The model of line graph has good distinction and accuracy.Elevated NLR(HR 3.258,95%CI 1.678～4.694)and high baseline NLR(HR 2.365,95%CI 1.547～4.526)were independent risk factors for new DPN after 1 year in the DPN-free group(P<0.05).There is a significant negative correlation between NLR and nerve conduction velocity in patients with T2DM(P<0.05).Conclusions Within the baseline normal range,the higher the NLR ratio,the greater the risk of DPN and the slower nerve conduction velocity,which is not conducive to the prognosis of patients.
